Lion's Mane (Hericium erinaceus) is, perhaps, the single functional mushroom that has been of interest to neuroscientists, biohackers, and wellness brands alike. It is called so because of its unique cascading white spines which appear like the mane of a lion and it is quickly becoming the nootropic ingredient of the 21st century.

Azoth Biotech is a producer of high-quality Lion’s Mane mushroom extracts in a dual-extracted, standardized, certified form to wellness brands that aim to take the lead in the booming cognitive health supplement sector.

The Unique Bioactives That Make Lion's Mane Special
•    Hericenones (in fruiting body) - stimulate NGF production in the brain.
•    Erinacines (mycelial) - cross blood-brain barrier; strong NGF inducers.
•    Beta-glucans - gut health and immune modulation support.
•    Polysaccharides - anti-oxidant and anti-inflammatory.
•    Sterols and fatty acids - neuroprotective membrane support.

The erinacines coupled with hericenones are not found in any other natural source, and only Lion’s Mane activates the growth of the brain by stimulating Nerve Growth Factor (NGF) through the dual-compound stimulant effect.

The 9 Proven Health-Promoting Effects of Lion Mushrooms.

Stimulates the production of Nerve Growth Factor (NGF).
NGF is a protein necessary to grow, maintain, and survive neurons. Reduced levels of NGF have been linked to cognitive impairment, Alzheimer and Parkinson diseases. The sole known natural source of food containing compounds that can have a significant stimulatory effect on NGF production in the brain is Lion’s Mane - a finding that has massive potential consequences on the longevity of the human brain.

2. Improves Recollection and Thinking.
Several human clinical research studies such as the first ground-breaking Japanese trial show that Lion Mane supplementation has a significant positive effect on the scores on cognitive tests in mildly impaired adults. There was quantifiable memory, attention and speed of information processing improvements among the participants.

3. Decreases Anxiety and Depression Symptoms.
In a placebo-controlled, double-blind clinical trial of women, Lion's Mane supplementation over 4 weeks had a significant effect on anxiety and depression rating scales by lowering the scores. Researchers have also credited this to anti-inflammatory action of the gut-brain axis and BDNF (Brain-Derived Neurotrophic Factor) modulation.
4. Helps Nerve Injuries
Lion’s Mane has NGF-stimulating erinacines that can be promising in stimulating peripheral nerve repair and recovery. The capacity to cause faster functional recovery of nerve crush injuries in animals has proven to be an exciting prospect to neurological rehabilitation support products.

5. Prevents Alzheimer and Dementia.
It is also shown that Lion’s Mane lowers the build-up of amyloid-beta plaques - a symptom of Alzheimer disease - in animals. Multi-mechanism approach to Alzheimer prevention research: Its anti-neuroinflammatory effects as well as its NGF-stimulating effect offers a multi-mechanism approach to Alzheimer prevention research.

6. The Gut-Brain Axis and Gut Health.
The polysaccharides of Lion Mane are good prebiotics that stimulate the growth of good bacteria and prevent the growth of harmful bacteria. It has been shown that Lion's Mane can be used to heal the intestinal epithelial barrier (leaky gut), decrease gut inflammation, and could even prevent gastric ulcers all with the benefit of positively impacting mood through the gut-brain axis.

7. Immune System Enhancement
The Lion’s Mane beta-glucans stimulate the macrophages, dendritic cells and natural killer cells, which offer an effective immune surveillance and protection. Lion's Mane is safe to use every day with minimal stimulation and is recommended to healthy populations seeking to have a strong immune system.

8. Anti-Inflammatory and antioxidant effects.
Low-grade and chronic inflammation is a cause of practically all chronic diseases. Lion's Mane polysaccharides and phenolic compounds block major inflammatory pathways (NF-kB, COX-2) and counteract free radicals, which have a positive effect on overall health and healthy aging.

9. Potential Anti-Cancer Properties
Preclinical studies show that tumor cell proliferation and apoptosis of various cancer cell lines can be inhibited and induced by Lion's Mane extracts. Although this study is still in its initial phase, it contributes to the impressive practical profile of Lion Mane as a well-being compound.

Who is the Lion Mane Supplementation Benefiting the most?

•    Knowledge workers and students in need of cognitive advantage and concentration.

Older adults with fears of memory and cognitive decline.
•    People who cope with anxiety, stress, or low mood.
•    Athletes who want to recover faster and those in need of nervous system support.
•    Individuals with intestinal problems such as leaky gut and IBS.

Anyone who is investing in long-term neuro-protection and brain health.

Product Applications: Formulating with Lion's Mane Extract
Nootropic capsules and brain health supplements.
•    Functional coffee and mushroom tea blends
•    Sports nutrition and protein powders.
•    Chewable and gummy cognitive health supplements.
Skincare with neuroinflammation and aging-targeting formulations.

Azoth Biotech's Lion's Mane Extract: The Gold Standard for B2B Partners

The Lion's Mane extract of Azoth Biotech is produced through organically grown fruiting bodies with a fine-tuned dual-extraction procedure - retaining the entire range of hericenones, erinacines, and polysaccharides that characterize Lion's Mane bioactivity.
Or - Standardized beta-glucan content (minimum 30%)
•    HPLC-verified hericenone profile
•    In the form of water extract, ethanol extract or dual extract powder.
•    Organic certified, ISO 22000, HACCP and FSSAI compliant.
•    Regulatory documentation and support on technical formulation.
•    White-label, its own label, and contract manufacturing opportunities.

Dosage Guidance
Common dosage: 500 mg -1000 mg/day of standardized extract to benefit the brain and cognition.
Improved protocol: Intensive neuroprotection up to 3,000 mg/day or clinical-level uses.
The R&D department of Azoth Biotech offers complete dosage optimization and formulation consultation in your desired format of product.

In conclusion, Lion Mane - The hottest functional ingredient of our age.
Lion Mushroom is the most potent nootropic in nature because in the world where cognitive performance, mental health and life span of the brain is the number one consumer priority, Lion Mushroom is the only mushroom in nature that is strong. Its ability to activate NGF, maintain the gut-brain axis, mood control, and neurodegeneration protection, is unique and makes it a backbone ingredient of any serious wellness brand.

Azoth Biotech is proud to be able to provide the best quality Lion's Mane extracts to brands that will not sacrifice science, quality or consumer impact. Contact us today to order samples, technical information or a consultation on formulation.